EPA Updates New Approach Methods to Replace Animal Testing for Chemical Assessments

Short summary

EPA announced June 2, 2026 updates to eliminate animal testing for chemical assessments, adding 13 new validated alternatives to its approved NAM list with a goal of phasing out all mammalian testing by 2035. These modern methods—human cell models and computer-based approaches—reduce testing costs, time, and animal use while producing more human-relevant safety data. The shift reflects global regulatory acceleration, particularly in the EU under REACH and across Asia-Pacific jurisdictions.

• •EPA added 13 new approved New Approach Methods (NAMs) for chemical safety testing, replacing animal-based assessments
• •Target of zero mammalian animal testing by 2035 with methods that reduce costs, time, and animal use
• •Global trend accelerating in EU, Asia-Pacific; OECD harmonization enables cross-jurisdiction acceptance

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